Serotonin is the first the first supplement we are going to talk about. This is a supplement readily available in a commercial form called 5 hydroxytryptophan (5HTP). In fact this is a precursor to serotonin, which means it is a building block the body can quickly absorb to create serotonin.
5 HTP is sold as a mood enhancing supplement and is classified as a monoamine oxidase inhibitor (MAOI). Like St John’s Wort, it is a very light MAOI and the dosage used for LDing is also very low. An MAOI works by preventing the breakdown of monoamine neurotransmitters, which are responsible for conducting information from one nerve to another.. By preventing the breakdown of the neurotransmitters in the nerve synapse (space between two nerves), the activity of the nerve impulse is allowed to continue with more efficiency, even after the stimulus has ceased. In other words, we are forcing the activity of a particular neural response, despite the lack of stimulus.
One of the properties of 5 HTP is that it can block REM activity during sleep. This allows us a wonderful method to take control of the REM drive. A dose 0f 100-150mg taken at bed time will be enough to block REM activity for 4-5 hrs. The supplement is quickly absorbed and quickly used up by the body so by the time the 4-5 hrs is up; we are going to be pretty clear of it from the body.
This causes REM rebound to occur and can offer fantastic leverage to enter the lucid state as we will experience more intense, stable and predictable REM activity which suffice to say is exactly what we want to have intense dreams.
I refer to this supplement as the blue pill as to some extent, it does the exact opposite to acetylcholine, which is commonly referred to as the red pill. 5 HTP is taken at bed time and a sleep period of 4-5 hrs must follow. This period of sleep will consist mostly of slow wave or non REM sleep, building up the REM for the rebound where we will be waiting to hijack it.
Some considerations about 5 HTP, this is an MAOI and therefore by definition can be used to treat depression (closer to 500mg daily). Therefore anyone taking any kind of antidepressant medication would be well advised to seek medical advice before consuming it.
Furthermore there can be a side effect of nausea or gastrointestinal upset. Though I have not experienced this and this likely due to the low dose needed for LD-ing, I would none the less advise anyone who is using this method to start with a low dose to check the response and gradually increase the dose. Perhaps as low as 50mg can be a start, gradually increasing up to 100mg or 150mg. I personally use 100mg for very good results and no side effects.